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Cheap Flights from Ohio to South Carolina - Compare Flight Deals & Schedules

With plenty of flights available from Ohio to South Carolina, travelers have a wide range of choices to plan their journey more conveniently. Browse one-way fares from $53.99, round-trip fares from $103.98, and other affordable flight options that fit different budgets and preferences. Explore available schedules, compare airline services and choose the most suitable flights from Ohio to South Carolina for your travel plans.

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Cheap Flights from Ohio to South Carolina from from $53.99

Find cheap flights from Ohio to South Carolina and compare the latest fares across popular routes such as Ohio to South Carolina. Book affordable flight deals with CheapOair and save on your next trip. Call us for phone only deals at 
One Way Round Trip
CLE Cleveland Sun, Aug 23
MYR Myrtle Beach
from $54
Book Now
CVG Cincinnati Thu, Sep 10
CHS Charleston
from $75
Book Now
CAK Akron-Canton Fri, Aug 21
CHS Charleston
from $137
Book Now
CMH Columbus Tue, Aug 11
CHS Charleston
from $137
Book Now
CLE Cleveland Wed, Aug 26
CHS Charleston
from $139
Book Now
CVG Cincinnati Mon, Aug 3
GSP Greenville
from $142
Book Now
CAK Akron-Canton Sat, Aug 15
MYR Myrtle Beach
from $147
Book Now
CMH Columbus Fri, Sep 18
GSP Greenville
from $162
Book Now
CVG Cincinnati Mon, Aug 17
MYR Myrtle Beach
from $230
Book Now
DAY Dayton Wed, Aug 12
CHS Charleston
from $291
Book Now
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*All fares above were last found on:
Fares are one way/round trip. Fares incl. all fuel surcharges, taxes & fees and our service fees. Displayed fares are subject to change and cannot be guaranteed at the time of booking. See all booking terms and conditions. 202607~Ref:WHYDS3x4YUSYTu12wW6mqQ

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Better deals are one call away Call us Say and save Expires July 31, 2026. Where applicable discount applies to service fees for qualified airline tickets. Amount of service fee discount varies: maximum savings of $10 per person applied to bookings from one (1) traveler up to five (5) travelers; the maximum discount applied is $50. Promo Code and Instant Savings offers can be combined up to the amount of our service fees but cannot be used or combined with any other coupons, promotions or special offers. May be withdrawn at any time without notice. Promo code only applicable for bookings created over the phone through our call center.