server side global
12/22/2026
  • Flights
  • Packages
  • Hotels
  • Cars
Round-trip
Economy

Refine your search by airline, by city or airport or direct flights

Bundle & Save
Advanced search
Close

Cheap Flights from Italy to Spain - Compare Fares & Flight Options

With many daily flights from Italy to Spain, travelers can plan their trip with more flexibility and convenience. Browse one-way fares from $49.0, round-trip fares from $111.98, and other affordable flight options that fit different budgets and preferences. This international route is served by major airlines with both nonstop and connecting flights available throughout the week. Compare fare options, check schedules and book the best flights from Italy to Spain for your upcoming trip.

Book with Confidence. Trusted by 40M+ Travelers
Price Match Promise  
Found a better deal? We'll match it!
Get Real Help, 24/7
Skip the bots. Talk to a real travel expert.
ClubMiles Rewards
Stack points & airline miles to save.
Easy Cancellations
Convenient options online and 24/7 global concierge.

Cheap Flight Deals from Italy to Spain

Explore the latest cheap flight deals from Italy to Spain and compare fares across popular routes. Whether you're planning a one-way or round-trip journey, CheapOair helps you find competitive prices and book flights with confidence. Call us for phone only deals at 
One Way Round Trip
MIL Milan Tue, Dec 22
BCN Barcelona
from $49
Book Now
VCE Venice Sun, Nov 22
MAD Madrid
from $55
Book Now
GOA Genoa Sun, Feb 28
MAD Madrid
from $61
Book Now
MIL Milan Sat, Nov 21
MAD Madrid
from $72
Book Now
ROM Rome Thu, Jan 14
MAD Madrid
from $91
Book Now
NAP Naples Tue, Sep 7
PMI Palma Mallorca
from $92
Book Now
VCE Venice Sun, Nov 22
BCN Barcelona
from $111
Book Now
FLR Florence Mon, Nov 9
BCN Barcelona
from $119
Book Now
FLR Florence Sat, Nov 28
MAD Madrid
from $120
Book Now
NAP Naples Wed, Jan 13
BCN Barcelona
from $135
Book Now
VCE Venice Wed, Aug 25
VLC Valencia
from $141
Book Now
FLR Florence Thu, Dec 31
VLC Valencia
from $182
Book Now
BLQ Bologna Fri, Feb 26
ALC Alicante
from $186
Book Now
VCE Venice Sun, Dec 13
PMI Palma Mallorca
from $265
Book Now
OLB Olbia Sun, Jun 6
PMI Palma Mallorca
from $277
Book Now
Show more
*All fares above were last found on:
Fares are one way/round trip. Fares incl. all fuel surcharges, taxes & fees and our service fees . Displayed fares are subject to change and cannot be guaranteed at the time of booking. See all booking terms and conditions . 202610~Ref:fzdrf77zbEmzQ7_zZh-5GQ

Flight Insights for Italy to Spain

Plan your trip with helpful insights for flights from Italy to Spain. Check the best time to travel, seasonal trends, average fares, and the lowest available prices to make a more informed booking decision.

Low Season*

March

High Season*

January

Cheapest Flight Found*

$49

MIL - Milan
12/22/2026
→
BCN - Barcelona
*Seasonality insights are based on booking trends from the last 12 months, and fare insights are based on the lowest price we've seen for this one way route in the last 12 hours. Prices may change and are not guaranteed for all flights or travel dates. Ref. id 202610~Ref:fzdrf77zbEmzQ7_zZh-5GQ

Recent posts View all posts
Find Your Perfect Island Match on National Cheap Flight Day
Read more
Dream Bucket-List Destinations to Book on National Cheap Flight Day
Read more
The Best Long-Weekend Destinations for National Cheap Flight Day
Read more
Great International Cities to Discover on National Cheap Flight Day!
Read more
5 Fall City Escapes to Consider on National Cheap Flight Day
Read more
View all posts

What do our customers say about our service?

Great | 4.1 Stars
Based on 34,320 reviews
Write a review Show more reviews
  • Helpful Assistance When my itinerary changed and the original flights no longer worked, the support representative quickly helped me find better alternatives. They were professional, courteous, and went above and beyond to resolve the issue. I'm grateful for the excellent assistance and smooth experience.

    Read more

    Aug 04, 2026 John Naples
  • Excellent Service I recently needed help with a flight schedule change and had a great experience with customer service. Laura was professional, friendly, and very helpful throughout the process. She quickly found a solution and kept me informed of the next steps. I truly appreciate her excellent service.

    Read more

    Jul 28, 2026 John Naples
  • Highly Recommended When my flight was unexpectedly canceled, I needed help rearranging my travel plans. The customer service representative was calm, professional, and extremely helpful throughout the process. They quickly found alternative flight options and assisted with the necessary follow-up. I truly appreciate the excellent support and dedication to resolving my issue.

    Read more

    Jul 16, 2026 Bernadine Janowitz
  • Great Prices offered CheapOair has always offered great prices, and my booking experience has been smooth and hassle-free every time.

    Read more

    Jul 15, 2026 Mike Mike
Write a review Show more reviews

Italy Travel Tools

  • No matter what your need or budget is we have a italy hotels that will suit your every need. Book now and get your reservation instantly!
  • Getting cheap italy car rentals has never been so easy! Now you can find and book unbelievable cheap rental cars in italy at just a snap of a finger.
  • You don’t have to wait for a lifetime to indulge in your dream vacation in italy. With italy vacation packages so cheap, now you can take a vacation anytime with CheapOair.

Spain Travel Tools

  • No matter what your need or budget is we have a Spain hotels that will suit your every need. Book now and get your reservation instantly!
  • Getting cheap Spain car rentals has never been so easy! Now you can find and book unbelievable cheap rental cars in Spain at just a snap of a finger.
  • You don’t have to wait for a lifetime to indulge in your dream vacation in Spain. With Spain vacation packages so cheap, now you can take a vacation anytime with CheapOair.

Flights from Italy

Flights to Spain

Flights from Italy to Other Popular Countries

Flights to Spain from Popular Countries

Earn 2X points on CheapOair app
App users save more
Save on your first app booking with promo code FLY100.
ⓘ
  • Earn up to 6X points
  • 24/7 priority support
  • In-App calls at no cost
  • Manage your bookings on the go
Switch to the app
Scan QR and install Scan QR and install

Award-winning assistance, affordable travel

  • Award-winning assistance, affordable travel

  •   American Business Awards
    2020 Gold Stevie – Product
    Management Team of the Year
  •   Stevie Awards for Sales & Customer Service
    2021 Bronze Stevie – Customer Service
    Department of the Year
  •  

Easy Access

Connect with Us
Have Questions?  Call us 24/7 000-800-050-3541
  • Quick Links
  • Popular Airlines
  • Popular Flight Routes
  • Top U.S. Destinations
  • Top International Destinations
Explore our cheap airfare options by carrier, with over 500 options to choose from.
Book one of our most popular flight routes with three easy clicks.
Find cheap airline tickets to popular U.S. destinations from coast to coast.
Get cheap air travel to global destinations in Europe, Asia and beyond.
partners logos

© 2006-2026 Fareportal, Inc. All rights reserved. Privacy Policy and agree to our Terms and Conditions. California: CST #2073455, Florida: ST37449, Hawaii - SOT#TAR-7560-0, Washington: WASOT #602755832 (affiliate of Travelong, Inc.)

Better deals are one call away Call us Say and save Expires Oct 31, 2026. Where applicable discount applies to service fees for qualified airline tickets. Amount of service fee discount varies: maximum savings of $10 per person applied to bookings from one (1) traveler up to five (5) travelers; the maximum discount applied is $50. Promo Code and Instant Savings offers can be combined up to the amount of our service fees but cannot be used or combined with any other coupons, promotions or special offers. May be withdrawn at any time without notice. Promo code only applicable for bookings created over the phone through our call center.