Hotels near Buffalo-Depew Amtrak Station are always on sale with CheapOair! Visit the Buffalo-Depew Amtrak Station that is housed in Depew, New York. This station is situated near the site where in 1893, Empire State Express Locomotives #999 attained its alleged top speed of 112.5 miles per hour (181 km/h) making it the fastest locomotive of its time. This station has three Amtrak services known as Empire Service, Lake Shore Limited and Maple Leaf. Find great deals on cheap hotels near Buffalo-Depew Amtrak Station, and count on CheapOair for all of your travel booking needs!